{"id":1714,"date":"2020-03-13T10:04:04","date_gmt":"2020-03-13T09:04:04","guid":{"rendered":"https:\/\/healthcareers.co\/?p=1714"},"modified":"2021-01-31T17:52:24","modified_gmt":"2021-01-31T16:52:24","slug":"what-is-coronavirus","status":"publish","type":"post","link":"https:\/\/healthcareers.co\/what-is-coronavirus\/","title":{"rendered":"What Is Coronavirus: A Comprehensive Overview of the Pandemic"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Mankind hasn\u2019t faced such a large-scale epidemic recently. For some people, it\u2019s about fear of the uncertainty and the risk of death, whereas for others, it\u2019s just another conspiracy theory. The truth is that, if asked \u201cW<\/span><span style=\"font-weight: 400;\">hat is Coronavirus<\/span><span style=\"font-weight: 400;\">?\u201d not many can answer precisely at this moment.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One thing that we know for sure is that this outbreak is a test of solidarity. We have to act together scientifically, politically, financially, and medically to end this infection that does not respect borders or restrictions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Research is an essential part of the fight against this common enemy. For this reason, here, we bring to the forefront the latest scientific facts on the natural history of the virus, <\/span><span style=\"font-weight: 400;\">coronavirus transmission<\/span><span style=\"font-weight: 400;\">, and diagnosis; epidemiological studies; clinical picture, infection prevention and control, research and development on candidate therapeutics and vaccines; and integration of social sciences into the outbreak response.<\/span><\/p>\n<h2><b>Top Coronavirus Outbreak Facts and Statistics<\/b><\/h2>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Diseases can make anyone sick, regardless of their race or ethnicity.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Coronavirus primarily binds to the receptors found in the lungs and small intestine.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">One person can infect 2-3 people.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Experts project that around 40 to 70% of people worldwide will be infected with the virus within the current year.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Two months after the outbreak started, 87% of the infected people were recovered or discharged, while the remaining 13% resulted in death.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">After the pandemic reached the population of 10,000,000 and the global anti-COVID measures applied, these figures changed to 93% of recovered or discharged, and 7% resulted in death cases.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">China, Italy, Spain, and South Korea were the first countries to lead in numbers of infected cases.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">After these countries, the USA, Germany, Spain, Switzerland, and Iran quickly rose in the number of new cases.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">It took CoVid-19 three months to infect more than a million people worldwide.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">By June 2020, the USA was still leading in the number of new cases, while Brazil, India and Russia closely followed.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The virus is more quickly spread through aerosolized droplets that saturate the air in places of high disease prevalence.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The available data suggests that the recent outbreak with nCoV-19 has emerged from an animal reservoir.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">How the infection will evolve depends on the person\u2019s immune response.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">In older people with chronic diseases such as diabetes, cardiovascular disease, respiratory issues, cancer, and more, the immune system may not be able to cope with the virus.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Mortality is highest in people over 80 (14.8%).<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">The timeline for a vaccine development can be compressed, but it still takes at least 12 months to create a compelling and safe vaccine.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Someone who has completed quarantine or has been released from isolation does not pose a risk of infection to other people.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Even with ideal restriction and quarantine measures, the spread of the virus may have been inevitable.<\/span><\/li>\n<\/ul>\n<h2><b>The Biology and Genetics of <\/b><b>Human Coronavirus<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Coronaviruses belong to a large family of viruses responsible for diseases ranging from mild to more severe, such as:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Middle Eastern Respiratory Syndrome (MERS-CoV), and\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Severe Acute Respiratory Syndrome (SARS-CoV).\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The new coronavirus (nCoV-19) has emerged in China and has not been observed in humans until now.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">And what\u2019s even more intriguing, the experts believe that the already identified coronaviruses might only be the <\/span><b>tip of the iceberg<\/b><span style=\"font-weight: 400;\">. This means that more novel and potentially severe zoonotic diseases are expected to be revealed in the future.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Corona viruses<\/span><span style=\"font-weight: 400;\"> are <\/span><i><span style=\"font-weight: 400;\">zoonoses<\/span><\/i><span style=\"font-weight: 400;\">, which means they are transmitted from animals to humans. However, several known corona family members circulate only in animals.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Coronaviridae family is composed of <\/span><a href=\"https:\/\/virologyj.biomedcentral.com\/articles\/10.1186\/s12985-019-1182-0\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">single-strand RNA viruses<\/span><\/a><span style=\"font-weight: 400;\">, with genomes ranging from 26 to 32 kilobases in length. These viruses can infect several avian hosts and mammals, including bats, mice, dogs, and cats.\u00a0<\/span><\/p>\n<p><b>Due to the high rate of mutations and recombination events, their virulence can improve over time. This diversity leads to better replication in human cells and a greater capacity to cause disease.<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Furthermore, the first cases of laboratory-confirmed nCoV-19 disease (<\/span><a href=\"https:\/\/www.who.int\/health-topics\/coronavirus\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">COVID-19<\/span><\/a><span style=\"font-weight: 400;\">) defined the primary pathogenetic mechanism of the virus \u2013 pneumonia and acute respiratory distress syndrome (ARDS) that require intensive care treatment.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">NCoV-19 binds to the receptor protein called ACE2, common also for the other <\/span><span style=\"font-weight: 400;\">SARS coronaviruses<\/span><span style=\"font-weight: 400;\">. This receptor is found in the <\/span><span style=\"font-weight: 400;\">human epithelia of the lung and small intestine<\/span><span style=\"font-weight: 400;\">, which explains the leading symptoms of the disease. It also reveals the pathogenesis and treatment options for the disease <\/span><span style=\"font-weight: 400;\">COVID-19<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2012-7\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">genetic analysis <\/span><\/a><span style=\"font-weight: 400;\">indicates that nCoV-19 shares nucleotide sequences with SARS-CoV (94.4%), the two bat-derived SARS-like coronaviruses (88%), SARS-CoV (79%) and MERS-CoV (50%).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There are <\/span><a href=\"https:\/\/www.cdc.gov\/coronavirus\/types.html\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">four nCoV-19 types<\/span><\/a><span style=\"font-weight: 400;\"> such as <\/span><span style=\"font-weight: 400;\">human coronavirus nl63<\/span><span style=\"font-weight: 400;\">, <\/span><span style=\"font-weight: 400;\">human coronavirus 229e<\/span><span style=\"font-weight: 400;\">,<\/span><span style=\"font-weight: 400;\"> human coronavirus oc43<\/span><span style=\"font-weight: 400;\">, and <\/span><span style=\"font-weight: 400;\">human coronavirus hku1<\/span><span style=\"font-weight: 400;\">, which may differ slightly in their clinical picture and the target group of patients.<\/span><\/p>\n<h3><b>The New Evidence for <\/b><b>Coronavirus Mutations<\/b><b>\u00a0<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Since February 28th, <\/span><a href=\"https:\/\/www.sciencemag.org\/news\/2020\/03\/mutations-can-reveal-how-coronavirus-moves-they-re-easy-overinterpret\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">more than 350 genome sequences<\/span><\/a><span style=\"font-weight: 400;\"> of CoVid-19 virus have been determined and publicly disclosed.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In general, the virus genome detected in China resembles those currently studied in Europe.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">According to a recent <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32171191\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">study<\/span><\/a><span style=\"font-weight: 400;\">, genome sequences between the 29 strains detected in China, were in 99.9% similar to those found in Japan, USA, and Finland.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">So far, the scientists determined that the virus has <\/span><a href=\"https:\/\/www.sciencedaily.com\/releases\/2020\/03\/200317175442.htm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">natural origin<\/span><\/a><span style=\"font-weight: 400;\">, and retains its evolutionary reproduction paths. In other words, it has not been chemically altered in any way. However, the coronavirus species is proven to be susceptible to <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4369385\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">human-related mutations<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">So far, Spanish scientists detected <\/span><a href=\"https:\/\/www.express.co.uk\/news\/world\/1257128\/coronavirus-new-strain-spain-italy-china-latest-covid-19-europe-wuhan\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">nine<\/span><\/a><span style=\"font-weight: 400;\"> mutations of the virus, while the ones in Brazil found sixteen differing genome variables.<\/span><\/p>\n<h2><b>Epidemiological <\/b><b>Information About Coronavirus<\/b><\/h2>\n<h3><b>Geographical Distribution<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">At the end of 2019, The World Health Organization (WHO) identified the zoonotic coronavirus, tentatively labeled as 2019-nCoV, as the causative agent of the viral pneumonia outbreak in Wuhan, China. It is not yet known whether temperature changes during seasonal transitions may affect the spread of the virus, like they do for other infections, such as <\/span><a href=\"https:\/\/healthcareers.co\/flu-statistics\/\"><span style=\"font-weight: 400;\">influenza<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, the infection continues to spread. One hundred million people have been restricted to the area around Wuhan, but the infection has spread to other countries.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Despite the apparent ineffectiveness of the measures to stop this <\/span><span style=\"font-weight: 400;\">human SARS coronavirus<\/span><span style=\"font-weight: 400;\"> from spreading, or at least to prevent the social and economic damage, repression continues to escalate.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Under the political pressure to \u201cshut down\u201d the virus, the Chinese government announced that employees in Hubei Province would go door to door, test people for fever, look for other <\/span><span style=\"font-weight: 400;\">symptoms of virus<\/span><span style=\"font-weight: 400;\"> presence, and then send all potential quarantine cases to be tested for the virus.\u00a0<\/span><\/p>\n<p><b>But even with ideal restriction and quarantine measures, the spread of the virus may have been inevitable.<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Testing people who are already extremely ill is not a good strategy, given that those who feel well and do not show any <\/span><span style=\"font-weight: 400;\">coronavirus disease symptoms<\/span><span style=\"font-weight: 400;\"> can spread the virus.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Italy, Iran, and South Korea are already among the countries reporting the rapidly increasing number of confirmed <\/span><span style=\"font-weight: 400;\">COVID-19<\/span><span style=\"font-weight: 400;\"> infections. These countries are also attempting to implement the repression measures that have been proven ineffective. After all,<\/span><b> dealing with a pandemic will require opening borders, not closing them.<\/b><\/p>\n<h2><b>Spreading of the <\/b><b>Human SARS Coronavirus<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The new <\/span><span style=\"font-weight: 400;\">coronavirus definition<\/span><span style=\"font-weight: 400;\"> states that it is an airborne respiratory virus.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This means that the infection is spread by droplets containing the virus released into the air by the infected people during sneezing, coughing, and talking.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Coronavirus can also be transmitted by touching virus-infected surfaces and then touching your eyes, mouth, or nose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In other words, touching contaminated surfaces such as door handles, elevator knobs, stair railings, public transport pick-up points, and then your face, can lead to the infection. Since it is <\/span><b>not yet clear how long the virus can persist on the surfaces<\/b><span style=\"font-weight: 400;\">, it is recommended to avoid touching them and to wash your hands frequently.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As far as we know, the concentration of aerosolized droplets is <\/span><a href=\"https:\/\/www.wired.com\/story\/how-long-does-the-coronavirus-last-on-surfaces\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">much higher<\/span><\/a><span style=\"font-weight: 400;\"> in environments with high disease prevalence, such as hospitals and help centers.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The viral particles, when inhaled or even digested by another person, are the most probable <\/span><span style=\"font-weight: 400;\">causes of coronavirus<\/span><span style=\"font-weight: 400;\"> infection.\u00a0<\/span><\/p>\n<h3><b>How to Keep Safe?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">It is essential to practice excellent hygiene by using masks, sneezing and coughing in the elbow\/sleeve fold, together with washing your hands frequently and disinfecting surfaces.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/healthcareers.co\/alcoholism-statistics\/\"><span style=\"font-weight: 400;\">use of alcoholic solutions<\/span><\/a><span style=\"font-weight: 400;\"> and bleach on the body cannot affect the virus that has already invaded the body. At the same time, these solutions can damage your skin, mucous membranes (eyes, mouth, nose) and your clothes, so it is not recommended to spray them on your body.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Washing your hands before preparing and consuming food is another good preventative measure for the spread of the virus.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The question \u201c<\/span><span style=\"font-weight: 400;\">is coronavirus contagious<\/span><span style=\"font-weight: 400;\">\u201d can be answered with a resounding \u201cyes,\u201d beyond any doubt. Based on the sometimes lacking <\/span><span style=\"font-weight: 400;\">coronavirus symptoms in humans<\/span><span style=\"font-weight: 400;\">, even when infected, it is assumed that the nCoV-19 is characterized by relatively low pathogenicity.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">There is increasing data about the biological and epidemiological features of the virus, but still, we do not have all the answers. SARS-CoV-2 pandemic remains a huge challenge because of these characteristics. Adapted to the human body, the virus dispersed over a brief amount of time across the planet. It is easy to apply the air-drop mechanism. Furthermore, the distribution of SARS-CoV-2 is due to the fact that COVID-19 exists in a mild form in around 85% of the infected people.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The transmissibility seems moderate to low as well \u2013 one person can infect 2-3 people. When the transmission rate drops below 1, we can talk about the control of the outbreak.<\/span><\/p>\n<h2><b>Respiratory Syndrome Coronavirus Outbreak<\/b><b> History<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The previous two epidemics concerning the representatives of the coronavirus family were more severe symptom-wise than the current outbreak.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">SARS-CoV and MERS-CoV infections exhausted people for hours, no asymptomatic cases were reported, and the mortality reached 40%. These patients were unable to go out, work, or travel around the country and worldwide. For this reason, the outbreaks were confined to regional epidemics and did not spread worldwide. To sum up, less than 1,000 people were killed by the SARS and MERS epidemics.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The new coronavirus is a beta coronavirus, and like the other <\/span><span style=\"font-weight: 400;\">coronavirus types<\/span><span style=\"font-weight: 400;\">, MERS-CoV and SARS-CoV, it has origins in bats. There is enough data available, suggesting that the recent outbreak with nCoV-19 has emerged from an animal reservoir.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It was noted that in Wuhan, Hubei Province, China, the origin of the outbreak, many affected people had visited seafood and live-animal markets, suggesting the initial animal-to-person spread. This was probably the first step in the evolution of the new coronavirus. Then, the infection started to spread from person to person, since most of the patients with <\/span><span style=\"font-weight: 400;\">coronavirus disease symptoms<\/span><span style=\"font-weight: 400;\"> were not exposed to animal markets. This spread was reported outside Hubei and in countries outside China.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Subsequently, the community spread turns out to be the leading way of infection, meaning that some infected people don\u2019t know how or where they became exposed.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although <\/span><span style=\"font-weight: 400;\">COVID-19<\/span><span style=\"font-weight: 400;\"> has killed nearly three times as many people so far, <\/span><b>it is not as deadly as the previous coronaviruses or seasonal flu<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">By affecting people slightly or asymptomatically (over 82% of cases), it allows them to move freely around the world, reaching even more people. It is assumed that the transfer of the virus from animals to humans was intended for the virus to be more widespread, and this does not include killing the human host.<\/span><\/p>\n<h2><b>Immunological and <\/b><b>Virulence Factors of SARS Coronavirus<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">What happens to our body when infected with nCoV-19 has not yet been fully explained. However, the typical biological behavior of other coronaviruses and how the immune system copes with them have been described.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The immune system is the first to get triggered. Considering the variability of these viruses, they can also <\/span><i><span style=\"font-weight: 400;\">suppress the secretion of some interferons in the body<\/span><\/i><span style=\"font-weight: 400;\">. These molecules are a part of the body\u2019s innate protection against microorganisms, especially viruses. In this way, viruses try to counteract and block the immune system.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In fact, how the <\/span><span style=\"font-weight: 400;\">human SARS coronavirus<\/span><span style=\"font-weight: 400;\"> infection will evolve depends on the person\u2019s immune response. Moreover, the outcome and recovery also depend on other factors such as the infected person\u2019s age, sex, and accompanying chronic diseases.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">So far, in older people with chronic diseases such as <\/span><a href=\"https:\/\/healthcareers.co\/diabetes-statistics\/\"><span style=\"font-weight: 400;\">diabetes<\/span><\/a><span style=\"font-weight: 400;\">, <\/span><a href=\"https:\/\/healthcareers.co\/stroke-statistics\/\"><span style=\"font-weight: 400;\">cardiovascular<\/span><\/a><span style=\"font-weight: 400;\"> disease, respiratory issues, cancer, and more, the immune system may not be able to cope with the virus.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The clinical course of the infection could also be unfavorable for some young and healthy people in whom the immune system overreacts and spills many immune molecules into the bloodstream. The uncontrolled immune response, or the so-called \u201ccytokine storm,\u201d causes systemic inflammation and damage to organs, which belongs to the severe <\/span><span style=\"font-weight: 400;\">human Coronavirus symptoms<\/span><span style=\"font-weight: 400;\">, usually leading to death. This may have caused the death of 34-year-old <\/span><a href=\"https:\/\/www.economist.com\/china\/2020\/02\/13\/li-wenliangs-death-exposes-the-costs-of-chinas-authoritarianism\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Chinese doctor Li Wenliang<\/span><\/a><span style=\"font-weight: 400;\">, who was the first to alarm the world about the new virus.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Interestingly, Chinese doctors have registered more than 200 cases of re-infection with the new coronavirus in Wuhan, which may be due to insufficient immunological memory.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It seems that the nCoV-19 does not produce lasting immunity or, in some people, despite the resolve of the infection, the immune response has not been sufficiently effective.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Still, the anti-coronavirus antibodies are studied \u2013 are they protective, and what are the levels that wouldn\u2019t allow reinfection? Other factors that can influence immunity are immunodeficiencies, malnutrition (especially with proteins), immunosuppressive therapy, etc.<\/span><\/p>\n<p><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2026116?query=recirc_curatedRelated_article\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">A recent study from Iceland<\/span><\/a><span style=\"font-weight: 400;\"> demonstrated that the host&#8217;s immunity to this unpredictable and highly contagious <\/span><span style=\"font-weight: 400;\">SARS coronaviru<\/span><span style=\"font-weight: 400;\">s may not be transient but similar to that caused by other most common viral infections. In a blood test of those who survived, 1,107 out of 1,215 people had antibodies. In some of these people, the researchers found that antibody levels increased in the second month after diagnosis and remained in the blood for the next 2 months.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Another interesting fact is that antibody levels were higher in the elderly and those who had a more severe infection. Moreover, women had lower levels of antibodies than men, and smokers had lower levels than non-smokers.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The Icelandic study shows that new, different antibodies to the virus appear a few months after the <\/span><span style=\"font-weight: 400;\">coronavirus symptoms<\/span><span style=\"font-weight: 400;\">. They are probably more lasting and efficient. The second wave of antibodies is likely to be produced by a smaller number of longer-lived plasma cells that provide long-lasting immunity. However, more testing for antibodies against SARS-CoV-2 is needed. Immune responses vary considerably from individual to individual, and it is not yet clear whether antibodies can prevent recurrence and provide long-term immunity.<\/span><\/p>\n<h2><b>What are the Symptoms of Novel Coronavirus<\/b><b>?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The main signs of infection are respiratory symptoms, accompanied with fever, coughing, and difficulty breathing. In patients with more severe <\/span><span style=\"font-weight: 400;\">corona disease<\/span><span style=\"font-weight: 400;\">, the virus can cause pneumonia, severe acute respiratory syndrome (SARS), kidney failure, and even death.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The fever is usually presented as a high temperature (over 38\u25e6\u0421).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The initial pneumonia is characterized by a severe dry cough and difficulty breathing, but this is generally observed after a week (5-13 days on average). For these complaints, about 20% of patients will need hospital treatment.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The statistics show that <\/span><i><span style=\"font-weight: 400;\">80% of cases are fortunately mild,<\/span><\/i><span style=\"font-weight: 400;\"> with many asymptomatic patients. The majority of patients only have <\/span><span style=\"font-weight: 400;\">Coronavirus fever symptoms<\/span><span style=\"font-weight: 400;\"> or flu-like symptoms, and they can recover at home. On the other hand, <\/span><i><span style=\"font-weight: 400;\">13.8% of infected people develop severe symptoms<\/span><\/i><span style=\"font-weight: 400;\"> with pneumonia and shortness of breath. Almost <\/span><i><span style=\"font-weight: 400;\">5% of patients are critical,<\/span><\/i><span style=\"font-weight: 400;\"> requiring life-supporting procedures due to respiratory failure, septic shock, and multi-organ failure.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Asymptomatic <\/span><span style=\"font-weight: 400;\">COVID-19<\/span><span style=\"font-weight: 400;\"> can also occur &#8211; about 40% of those infected never develop typical <\/span><span style=\"font-weight: 400;\">coronavirus symptoms<\/span><span style=\"font-weight: 400;\">. However, these coronavirus carriers should not be underestimated because people who test positive for SARS-CoV-2 but who have never felt unwell may also have changes in their lungs and heart. No one still knows exactly whether the pathological changes will remain or disappear as the infection progresses.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Doctors hope that young and healthy people with a large lung reserve will not have problems later in life after <\/span><span style=\"font-weight: 400;\">coronavirus infection treatment<\/span><span style=\"font-weight: 400;\">. Nevertheless, some patients with <\/span><span style=\"font-weight: 400;\">COVID-19<\/span><span style=\"font-weight: 400;\"> get tired more easily and cannot train as intensely as before.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This is particularly relevant in children with COVID-19 who have the highest life expectancy. Moreover, a condition similar to Kawasaki disease can also be seen in children.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additionally, conditions such as heart arrest, kidney failure, liver failure, sepsis, lung scars, etc. can occur after infection with SARS-CoV-2, leading to death. These data help us understand more about what increases the risk of poor prognosis due to COVID, but this does not change the fact that COVID is more deadly than other viruses. Sometimes there are many contributing factors, although the main cause of death remains COVID-19.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In fact, about 94% of people who die from <\/span><span style=\"font-weight: 400;\">COVID-19<\/span><span style=\"font-weight: 400;\"> in the US have had 2-3 other comorbidities, <\/span><a href=\"https:\/\/www.cdc.gov\/nchs\/nvss\/vsrr\/covid_weekly\/index.htm?fbclid=IwAR3-wrg3tTKK5-9tOHPGAHWFVO3DfslkJ0KsDEPQpWmPbKtp6EsoVV2Qs1Q#Comorbidities\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">according to new data released by the CDC<\/span><\/a><span style=\"font-weight: 400;\">. This means that in only 6% of deaths, <\/span><span style=\"font-weight: 400;\">SARS coronavirus<\/span><span style=\"font-weight: 400;\"> disease is cited as the sole cause.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In addition to the lungs and liver damage, complaints such as rash, blood clots, reddish-purple spots on the fingers and toes are rare. Most have suffered from conditions such as respiratory failure, increased blood clotting and stroke, which can be caused by the coronavirus itself. Others had major illnesses such as hypertension, heart failure, sepsis and diabetes that existed before. Recently, the emerging data indicated that COVID-19 increased the risk of thromboembolic complications due to the associated hypercoagulable condition.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is worth mentioning that, unlike the common cold, the typical <\/span><b>coronavirus symptoms<\/b><b> do not include a runny nose, sneezing, or sore throat.<\/b><span style=\"font-weight: 400;\"> Nevertheless, about 5% of patients were described with these symptoms. However, when we compare <\/span><span style=\"font-weight: 400;\">rhinovirus vs coronavirus<\/span><span style=\"font-weight: 400;\"> infections, the similarities are fewer than the differences.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When suspecting <\/span><span style=\"font-weight: 400;\">COVID-19<\/span><span style=\"font-weight: 400;\"> infection, it is also essential to take into account the additional factors such as traveling to the epidemic regions in the last 14 days, or having close contact with an infected person.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The potential complications of the new coronavirus infection may include MERS, SARS, pneumonia that does not meet standard antibiotic treatment, and death. Infection with <\/span><span style=\"font-weight: 400;\">Coronavirus<\/span><span style=\"font-weight: 400;\"> during <\/span><span style=\"font-weight: 400;\">human pregnancy<\/span><span style=\"font-weight: 400;\"> can cause complications such as are premature birth, miscarriage, other health problems, or death at birth.<\/span><\/p>\n<h2><b>The Mortality Rate of <\/b><b>COVID-19<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Let us note that infection with the new coronavirus is not a death sentence. In fact, on average, about <\/span><b>98% of people who become infected will recover completely<\/b><span style=\"font-weight: 400;\">. The average mortality rate ranges between 2-3%, depending on the age, sex, the region of infection, and the presence of other serious diseases.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Currently, it is challenging to determine the actual mortality rate, as it is believed that not all the infected have sought medical attention and been registered. As a standard, the <\/span><span style=\"font-weight: 400;\">Coronavirus causes<\/span><span style=\"font-weight: 400;\"> high mortality among hospitalized patients. The augmented death rate was also reported in Wuhan (3.1%) and Hubei (4.9%), while in Europe, it is around 0.9%.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Mortality is highest in people over 80 (14.8%) because, in addition to the weaker immune system, they usually have several chronic conditions. For patients over 65, the mortality rate is also above 10%. Regardless of age, the presence of chronic respiratory, <\/span><a href=\"https:\/\/healthcareers.co\/heart-disease-statistics\/\"><span style=\"font-weight: 400;\">cardiovascular disease<\/span><\/a><span style=\"font-weight: 400;\"> (including <\/span><a href=\"https:\/\/healthcareers.co\/high-blood-pressure-statistics\/\"><span style=\"font-weight: 400;\">high blood pressure<\/span><\/a><span style=\"font-weight: 400;\">), cancer, or diabetes increases the risk of death after infection to 6-10.5%.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">On the other hand, for people between the ages of 10-60, the mortality rate is significantly lower, estimated at 0.2-0.4%, unless we are talking about <\/span><span style=\"font-weight: 400;\">Coronavirus and severe acute respiratory syndrome<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Interestingly, in men, the mortality rate is around 2.8% on average, compared to 1.7% in women.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is believed that many factors can play a role here, such as hormones, <\/span><a href=\"https:\/\/healthcareers.co\/smoking-statistics\/\"><span style=\"font-weight: 400;\">smoking<\/span><\/a><span style=\"font-weight: 400;\">, etc. Males usually have a more severe reaction to <\/span><span style=\"font-weight: 400;\">COVID-19<\/span><span style=\"font-weight: 400;\">, according to the preliminary data. Another explanation is related to the receptor through which the virus enters the cells. The encoding gene for the receptor is located on the X chromosome.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">But this observation can also be due to the greater number of smokers among men, which increases the risk of respiratory complications. Estrogens were shown to act protectively during the infection.<\/span><\/p>\n<h3><b>COVID-19 vs. Flu: Mortality Comparison<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">At the current stage of the COVID-19 pandemic, the actual mortality rate is impossible to estimate.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">So far, the data shows that the <\/span><b>crude mortality ratio<\/b><span style=\"font-weight: 400;\">, or the number of deaths divided by the reported cases, is around 3-4%.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In contrast to COVID-19, the seasonal flu usually kills fewer people, with a <\/span><a href=\"https:\/\/www.who.int\/news-room\/q-a-detail\/q-a-similarities-and-differences-covid-19-and-influenza\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">mortality rate below 0.1%<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, the infection mortality rate is a much precise parameter, which is calculated by dividing the number of reported deaths with the number of all infected with <\/span><span style=\"font-weight: 400;\">microorganism sars coronavirus people<\/span><span style=\"font-weight: 400;\">. In line with this, after the pandemic is over, it would be feasible to estimate the real mortality rate, and it is expected to be lower than what the current figures show.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When comparing mortality, it is important to take into account the differences in access to healthcare services and the quality of care of different regions.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The risk groups for each virus vary. In essence, children are <\/span><b>more susceptible to severe flu infections<\/b><span style=\"font-weight: 400;\">, as well as pregnant women, immunocompromised patients, people with underlying chronic medical conditions, and the elderly.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Officially, <\/span><b>the risk groups for severe COVID<\/b><span style=\"font-weight: 400;\"> are mainly older people and those with underlying chronic conditions. However, children and pregnant women have not presented severe cases so far.<\/span><\/p>\n<h2><b>Coronavirus in Infants<\/b><b> and Other Specific Groups of Patients<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">During the epidemic, it turns out that cases in children are rare. <\/span><b>Kids are more resistant to coronavirus infection<\/b><span style=\"font-weight: 400;\">, in contrast to their vulnerability to other infections, like flu. However, the data on <\/span><span style=\"font-weight: 400;\">coronavirus disease<\/span><span style=\"font-weight: 400;\"> in children are insufficient to conclude more. But no deaths have been reported in children under the age of 9.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The most vulnerable people remain the elderly, especially those over 80. Additional risk factors are gender and accompanying severe chronic conditions. Recent data from China suggest that those with chronic diseases are most likely to develop severe reactions.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Older people are also more prone to complications during this <\/span><span style=\"font-weight: 400;\">outbreak<\/span><span style=\"font-weight: 400;\"> of <\/span><span style=\"font-weight: 400;\">respiratory syndrome Coronavirus<\/span><span style=\"font-weight: 400;\">, such as severe untreatable pneumonia and shortness of breath, as well as respiratory failure, septic shock, and multiorgan failure &#8211; leading to death.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The mortality rate for people with cardiovascular disease is 10.5%. This percentage is 7.3% for patients with diabetes and about 6% for patients with chronic respiratory disease, hypertension, or <\/span><a href=\"https:\/\/healthcareers.co\/cancer-statistics\/\"><span style=\"font-weight: 400;\">cancer<\/span><\/a><span style=\"font-weight: 400;\">. Pregnant women are also a vulnerable group, with complications such as preterm birth.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Genetic and environmental factors can also influence the severity of infections. While genetic factors are still being studied in mice, smoking and polluted air are synergic harmful factors for the coronavirus infection.<\/span><\/p>\n<h2><b>Coronavirus Prevention<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The only way to protect against the infection right now is prevention. The WHO and other official sources of information have issued recommendations for compliance with high personal hygiene:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Frequent and thorough washing of hands with water and soap;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Use of disinfectants;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Proper wear of the protective mask and change at short intervals;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Avoiding travel to the regions with high infection rates;<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Avoiding close contact with people showing signs of respiratory infection (fever, coughing, sneezing);<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Staying at home if feeling sick.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Other useful recommendations to prevent the spread of infection, except regular hand washing, are covering the mouth and nose during sneezing and coughing, and thorough cooking of food (especially meat and eggs). Since there is no specific <\/span><span style=\"font-weight: 400;\">treatment of Coronavirus<\/span><span style=\"font-weight: 400;\">, all of these measures are the best ways of prevention.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If you do not live in an area where the virus is actively spreading, or if you have not traveled to affected areas or been in close contact with someone who has symptoms, is feeling unwell, or has been in the risk regions, the chances of getting sick are very low.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, it is understandable to <\/span><a href=\"https:\/\/healthcareers.co\/stress-statistics\/\"><span style=\"font-weight: 400;\">feel stressed and disturbed<\/span><\/a><span style=\"font-weight: 400;\"> by the situation. The more informed you are, the more appropriate measures you can take to protect yourself.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Additional preventive measures are avoiding public transport, not coughing and sneezing in the hands, performing immediate hand hygiene after touching public surfaces, and only being in enclosed places with proper ventilation, especially if you notice anybody showing <\/span><span style=\"font-weight: 400;\">coronavirus<\/span><span style=\"font-weight: 400;\"> or <\/span><span style=\"font-weight: 400;\">cold symptoms<\/span><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Symptoms of rhinovirus and coronavirus<\/span><span style=\"font-weight: 400;\"> are distinct since it is assumed that nCoV-19 doesn\u2019t affect the nose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">It is good to mention that masks should be worn by symptomatic people and <\/span><a href=\"https:\/\/healthcareers.co\/nursing-statistics\/\"><span style=\"font-weight: 400;\">people who provide medical care<\/span><\/a><span style=\"font-weight: 400;\"> to sick people. It is essential to prevent the spread of nCoV-19 by taking additional measures, including cancelling sport, cultural, scientific, and other types of events that could attract many people.<\/span><\/p>\n<h2><b>Is There a <\/b><b>Coronavirus Treatment<\/b><b>?<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">There is currently no specific treatment for the infection. Therefore, the recommended treatment remains to be only symptomatic. For this reason, prevention is the only way to protect against the spread of the virus.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, for patients with severe clinical presentation, treatment options include intensive care in order to support vital organ functions. In line with this, people who think they may have been exposed to nCoV-19 should contact their healthcare provider immediately. They will be instructed on how to proceed. If the chance of coronavirus infection is low, the patient will be advised to stay at home and seek medical help only in case of shortness of breath or other signs of complications.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nevertheless, there are some novel modalities for <\/span><span style=\"font-weight: 400;\">treatment of coronavirus <\/span><span style=\"font-weight: 400;\">related to the <\/span><a href=\"https:\/\/www.wjgnet.com\/1949-8454\/full\/v11\/i2\/14.htm\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">immunological mechanisms<\/span><\/a><span style=\"font-weight: 400;\">, such as plasma therapy, cytokines blockers, immunomodulators, mesenchymal stem cells (MSCs) therapy, etc.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Plasma therapy, or administration of antibodies obtained from the serum samples of reconvalescent people, are effective for both treatment and prevention. However, the anti-SARS-CoV-2 antibodies are more efficient when administered shortly after the onset of symptoms.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The goal of a prophylactic protocol for the use of passive immunotherapy is to prevent infection in highly risky people, medical professionals particularly, as well as in individuals with clinical presentations of infection to minimize the severity of complications and death.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Anti-inflammatory <\/span><span style=\"font-weight: 400;\">coronavirus infection treatment<\/span><span style=\"font-weight: 400;\">, including anti-cytokines and corticosteroids, can be efficient in patients, experiecing the cytokine storm, but they can not cure the disease solely. While the use of MSCs in severe cases of COVID-19 infection has been suggested in some clinics in China, as more potential anti-inflammatory action, no reliable findings have yet been reported.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, we have to keep in mind that although MSCs may be effective in suppressing the hyperactive immune response and promoting tissue repair in lungs, the use of MSCs in clinical practice should be limited to strict indications. We have to take into account the benefit-risk for each patient, including their oncogenic potential of MSCs.<\/span><\/p>\n<h2><b>The <\/b><b>Coronavirus Vaccine<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The good news is that after the rapid identification of the virus and revealing its genome, this information was shared with all scientists around the world. The global scientific community is now working together to create a vaccine, the Chinese government has introduced extreme repression measures, including <\/span><span style=\"font-weight: 400;\">coronavirus isolation precautions<\/span><span style=\"font-weight: 400;\">, and the WHO has declared a state of emergency of international importance.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The concern with the coronavirus comes from the fact that it is not clear for how long the virus will be active and spreading.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">At the present moment, the global race against time is the creation of an effective <\/span><span style=\"font-weight: 400;\">coronavirus vaccine injection<\/span> <span style=\"font-weight: 400;\">\u2013 <\/span><span style=\"font-weight: 400;\">one of the most evident strategies to save lives in the years to come.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">At the moment, a company has developed a product that uses small portions of the virus\u2019s RNA to introduce them to the immune system and build immunity against the whole virus.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This is the first promising step, but technically, it\u2019s far from a vaccine. Like other medicine, vaccines require a lengthy testing process to see if they are safe and effective.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Although genetic sequencing is now high-speed, vaccine making is as much of an art as it is science. It is necessary to find precisely the viral sequence that will lead to the creation of an effective and lasting immunological memory. The <\/span><span style=\"font-weight: 400;\">coronavirus vaccine schedule<\/span><span style=\"font-weight: 400;\"> depends on these factors but also many others. For example, it should not cause a sharp inflammatory response, such as \u201cflu-like symptoms.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Before being widely administered, such a vaccine should be tested in a laboratory, then on animals, and finally on humans.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Several biotech companies are working on this project at the same time, as well as academic institutes. The timeline for a vaccine development can be compressed, but it still takes at least <\/span><b>12-18 months to create a compelling and safe vaccine.<\/b><\/p>\n<p><span style=\"font-weight: 400;\">The challenges will then include other problems such as manufacturing and logistics, which can also be difficult due to the <\/span><a href=\"https:\/\/healthcareers.co\/unemployment-trends\/\"><span style=\"font-weight: 400;\">limited workforce<\/span><\/a><span style=\"font-weight: 400;\"> (especially as China\u2019s leading manufacturer) and closed international borders.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Even though there is no specific <\/span><span style=\"font-weight: 400;\">coronavirus infection treatment<\/span><span style=\"font-weight: 400;\">, the vaccine is a hope. However, this process can cost hundreds of millions of dollars <\/span><span style=\"font-weight: 400;\">\u2013<\/span><span style=\"font-weight: 400;\"> money that NIH, biotech companies, and universities don\u2019t have. Neither do they have the facilities and technologies for mass production and distribution of the vaccine. Thus, if you\u2019ve been wondering, \u201c<\/span><span style=\"font-weight: 400;\">is there a vaccine for just coronavirus<\/span><span style=\"font-weight: 400;\">?\u201d there probably won\u2019t be one available any time soon.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Coronaviruses can also be particularly challenging from a medical point of view. Due to their similarities to the flu viruses and the possibility of mutations, vaccines will also need to be in constant development, just like the flu shots. It may be too late to create a vaccine for this epidemic. Some experts believe that vaccine testing should have started with <\/span><span style=\"font-weight: 400;\">severe acute respiratory syndrome coronavirus<\/span><span style=\"font-weight: 400;\"> epidemic.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Currently, there is a vaccine being tested in Seattle, USA. The scientists at Moderna Inc. used already available knowledge about similar viruses to create a CoVid-19 vaccine at unprecedented pace. The testing started on March 16th 2020.<\/span><\/p>\n<h3><b>The Progress in the Making of the Vaccine<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">The humanitarian and economic crises that came subsequential to the COVID-19 pandemic are intensely fueling global research activity, especially for developing an effective vaccine against SARS-CoV-2.<\/span><a href=\"https:\/\/cepi.net\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">\u00a0<\/span><\/a><\/p>\n<p><a href=\"https:\/\/cepi.net\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">The Coalition for Epidemic Preparedness Innovations (CEPI<\/span><\/a><span style=\"font-weight: 400;\">) supports the next-generation vaccine technology platforms; thus, human clinical testing started on the 16th of March, which is unprecedentedly rapid.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Until the 8th of April, 115 vaccine candidates, of which 78 confirmed, are included in the global <\/span><span style=\"font-weight: 400;\">COVID-19 vaccine<\/span><span style=\"font-weight: 400;\"> R&amp;D landscape.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Amongst the different vaccine technologies being evaluated, the most promising are:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">DNA and RNA-based,\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Virus-like particles,\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Peptide-based, including coronavirus E protein vaccine approach,\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Viral vectors,\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Recombinant protein,\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Live-attenuated, or\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Inactivated virus.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">The<\/span><a href=\"https:\/\/www.nature.com\/articles\/d41573-020-00073-5\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\"> most advanced vaccine candidates<\/span><\/a><span style=\"font-weight: 400;\"> have already been put into clinical development:\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Moderna (mRNA-1273),\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">CanSino Biologicals (Ad5-nCoV),\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Inovio (INO-4800),\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Shenzhen Geno-Immune Medical Institute (LV-SMENP-DC and pathogen-specific aAPC).\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Other developers also declare initiating human testing in 2020.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The global efforts for COVID-19 development follow the trends of the vast scale and speed of the pandemic. Therefore, an effective vaccine is expected to be available sooner than usual.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, under emergency use, the official <\/span><span style=\"font-weight: 400;\">coronavirus vaccine<\/span><span style=\"font-weight: 400;\"> can be expected not before the beginning of 2021.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This fast-paced cure tracking demonstrates the fundamental step of jumping over the traditional pathway for vaccine development, which usually takes over ten years on average.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">More than 170 countries are ready to join the <\/span><span style=\"font-weight: 400;\">COVID-19<\/span><span style=\"font-weight: 400;\"> Vaccine Global Access Facility or COVAX, the <\/span><a href=\"https:\/\/www.who.int\/news-room\/detail\/24-08-2020-172-countries-and-multiple-candidate-vaccines-engaged-in-covid-19-vaccine-global-access-facility\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">WHO announced last week<\/span><\/a><span style=\"font-weight: 400;\">. The collaboration aims to accelerate the development of vaccines against SARS-CoV-22, produce enough doses for all countries and distribute them, especially to people who are at the highest risk of COVID-19 infection and complications. The <\/span><a href=\"https:\/\/www.gavi.org\/vaccineswork\/covax-explained\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">COVAX plan<\/span><\/a><span style=\"font-weight: 400;\"> is designed to focus on the high-risk people in all countries to get vaccines.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In fact, the process of developing vaccines requires a global network for the supply, production, and distribution of million doses for people, including syringes and vials.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To help accelerate the development and funding of the trials, the FDA and other federal agencies goal to deliver 300 million doses of a safe and effective <\/span><span style=\"font-weight: 400;\">coronavirus vaccine <\/span><span style=\"font-weight: 400;\">by January 2021. The program includes such companies as AstraZeneca, Janssen (Johnson &amp; Johnson), Moderna, Novavax, Pfizer, and Sanofi\/GSK. It is equally important for vaccine manufacturers to prove that the vaccines are safe. However, the FDA also stated that in some cases, emergency use of a vaccine against COVID-19 can be permitted.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nearly 200 vaccines for the disease are under study and several candidates have moved on to phase III human clinical trials. This is the last step in proving whether a vaccine is safe and effective before it receives FDA approval. In order for a <\/span><span style=\"font-weight: 400;\">coronavirus vaccine injection <\/span><span style=\"font-weight: 400;\">to be approved by the FDA, it will need to prevent infection or reduce its severity in at least 50% of vaccinated people.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The goal, as with any vaccination, is to immunize a large enough number of people with a vaccine so that the established immunity will last enough to prevent further dissemination of the virus. Thus, even the unvaccinated will be protected by herd immunity. To stop the current coronavirus pandemic, some experts believe that about 60% to 70% of the population should acquire antibodies, whether through a vaccine or through recovery from COVID-19.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">History has shown that only through vaccination, not through illness, such a disease can be eradicated. In other words, if not enough people are vaccinated and only the disease is relied on, collective immunity may not develop and <\/span><span style=\"font-weight: 400;\">coronavirus prevention <\/span><span style=\"font-weight: 400;\">will fail.<\/span><\/p>\n<h2><b>The Outlook for the Current Outbreak with the nCoV-19<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The world is responding to the epidemic at an unprecedented speed and mobilizing resources. Still, fear plays a critical role in the social and economic consequences. Some experts have made various assumptions, as it is believed that, as temperatures rise, the virus\u2019s viability in the environment will decrease. However, given the behavior of the virus and its characteristics, it is likely that <\/span><b>seasonal warming won\u2019t manage to restrict the spread of the virus in the coming months<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Since the development of vaccines and anti-coronaviral drugs for <\/span><span style=\"font-weight: 400;\">coronavirus treatment<\/span><span style=\"font-weight: 400;\"> in <\/span><span style=\"font-weight: 400;\">humans<\/span><span style=\"font-weight: 400;\"> is still ongoing, the official prognosis of the experts is for a pandemic. However, there are still preventive measures such as avoiding unnecessary travelling, airport stay, use of public transport, directed and unprotected close and physical contact with patients who have been diagnosed or suspect to have <\/span><span style=\"font-weight: 400;\">contracted a virus<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">More information regarding healthcare topics, you can find on <\/span><a href=\"https:\/\/healthcareers.co\/\"><span style=\"font-weight: 400;\">Healtcareers.co<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<hr \/>\n<h2><b>FAQ<\/b><\/h2>\n<h3><b>How long does coronavirus last<\/b><b>?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">If we assume that this virus is similar to the other coronaviruses, the new coronavirus may stay \u201calive\u201d on surfaces from a few hours to a couple of days. However, this also depends on the type of surface and environmental factors.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Regardless, surfaces have to be cleaned routinely with disinfectants. It is also essential to wash hands thoroughly and use alcohol-based hand sanitizer after touching potentially hazardous surfaces. Avoid touching your eyes, mouth, or nose.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">When inside the organism, the virus may take 14 days on average to cause infection and about a few days to be cleared. However, the severe illnesses related to the virus can last weeks.<\/span><\/p>\n<h3><b>Which disease is caused by coronaviruses<\/b><b>?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Coronaviruses are responsible for two main diseases &#8211; Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome. The nCoV symptoms range from mild, similar to the common cold, to more severe, such as those mentioned above. The disease, caused by the new coronavirus, is called <\/span><span style=\"font-weight: 400;\">COVID-19<\/span><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><b>What is SARS coronavirus<\/b><b>?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Also known as SARS-CoV, it is a virus discovered in 2003. Its origin is linked to animals \u2013 thought to be bats, and then civet cats. However, the animal reservoir is still unknown. SARS-CoV causes Severe Acute Respiratory Syndrome. The new coronavirus was firstly denoted as SARS-CoV-2, and later renamed to nCoV-19.<\/span><\/p>\n<h3><b>What is respiratory syndrome coronavirus<\/b><b>?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Middle East Respiratory Syndrome (MERS)-CoV can be transmitted between humans. However, the non-sustained human-to-human transmissions were observed mainly in healthcare settings. MERS-CoV is especially dangerous for people with underlying chronic medical conditions such as diabetes, renal and liver failure, chronic lung and cardiovascular disease, and compromised immune systems.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Except for general hygiene measures, food hygiene practices should also be observed. For instance, you should avoid consuming raw camel milk or meat that has not been properly cooked.<\/span><\/p>\n<h3><b>What is the test for coronavirus<\/b><b>?<\/b><\/h3>\n<p><span style=\"font-weight: 400;\">Initial testing recommendations for nCoV-19 are for people who have visited affected regions of the world or have had contact with someone who has been diagnosed with the disease. The standard test is based on the detection of RNA of the virus by real-time PCR. However, diagnostic tests are not done routinely, and they are not sufficient for making the diagnosis.<\/span><\/p>\n<hr \/>\n<h2><b>Conclusion<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">During the new coronavirus outbreak, it is essential to stay informed. Currently, this new virus is still affecting people in China, but it has spread to other countries too.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The good news is that most people who become infected will experience mild symptoms and recover completely. However, for others, it can be severe and fatal. For these reasons, it is critical to know the answer to \u201c<\/span><span style=\"font-weight: 400;\">what is coronavirus<\/span><span style=\"font-weight: 400;\">?\u201d and take preventive measures that can protect both you and those close to you.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mankind hasn\u2019t faced such a large-scale epidemic recently. For some people, it\u2019s about fear of [&hellip;]<\/p>\n","protected":false},"author":12,"featured_media":3634,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_jetpack_memberships_contains_paid_content":false},"categories":[133,156],"tags":[149,151,148,152],"acf":[],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"https:\/\/healthcareers.co\/wp-content\/uploads\/2021\/01\/covid.jpg","_links":{"self":[{"href":"https:\/\/healthcareers.co\/wp-json\/wp\/v2\/posts\/1714"}],"collection":[{"href":"https:\/\/healthcareers.co\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthcareers.co\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthcareers.co\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/healthcareers.co\/wp-json\/wp\/v2\/comments?post=1714"}],"version-history":[{"count":5,"href":"https:\/\/healthcareers.co\/wp-json\/wp\/v2\/posts\/1714\/revisions"}],"predecessor-version":[{"id":3655,"href":"https:\/\/healthcareers.co\/wp-json\/wp\/v2\/posts\/1714\/revisions\/3655"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/healthcareers.co\/wp-json\/wp\/v2\/media\/3634"}],"wp:attachment":[{"href":"https:\/\/healthcareers.co\/wp-json\/wp\/v2\/media?parent=1714"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthcareers.co\/wp-json\/wp\/v2\/categories?post=1714"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthcareers.co\/wp-json\/wp\/v2\/tags?post=1714"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}